Reproductive Consequences of Steroid Administration
The impact of long-term cross-sex hormone therapy on reproductive health in transgender men is largely unknown.National and international medical organizations recommend fertility preservation counseling prior to starting cross-sex hormone therapy, but these recommendations are based on an assumption of loss of fertility, not data. Data on histological changes in the human reproductive tract of transgender men (female-to-male or FTM) oncross-sex Testosterone (T)therapy arelimited to observational studies at the time of surgery, mostly with short-term T exposure and inconsistent results. For both adult and peripubertal treatment strategies, it is unknown if the effects of T treatment on reproductive function can be completely reversed by cessation of T, partially reversed, or if fertility preservation is the best means for safeguarding future fertility potential. We have created a mouse model to mimic T therapy for the FTM gender transition.These mice manifest defects in ovarian and uterine architecture. Creation of a FTM mouse model provides a powerful tool to clarify the effects of T therapy on fertility, in a manner not possible in humans. The goal of projects to use FTM mouse model to investigate the effects of cross-sex T treatment on reproductive phenotype and function, and determine the reversibility of these effects following cessation of T.